trailDietary cholesterol intake is not consistently associated with cardiovascular disease risk in the general population.
Dietary cholesterol overconsumption is not a significant health concern.
Epidemiological null / inconsistency· for
Dietary cholesterol intake has only a weak, variable effect on blood cholesterol levels.
A subset of people (hyper-responders) experience substantial blood cholesterol increases from dietary cholesterol intake.
✓
Dietary cholesterol intake suppresses endogenous cholesterol synthesis.
◌
Prospective cohort studies generally show no significant independent association between dietary cholesterol and cardiovascular disease.
Dietary cholesterol intake is confounded with saturated fat and other dietary risk factors.
shared · shown elsewhere
Positive dose-response and mechanism· against
Large pooled cohort studies find a dose-response association between dietary cholesterol intake and cardiovascular disease or mortality.
shared · shown elsewhere
assumed
Elevated LDL cholesterol causes cardiovascular disease
claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
Dietary cholesterol intake is not consistently associated with cardiovascular disease risk in the general population.
⇄ContestedCredible evidence or argument exists on multiple sides.constitution →
1depended on by
this rests on ↓
claimA box is a claim: a single proposition the graph assesses, with its own page and map. Click any claim to centre the map on it.constitution →argumentA pill is an argument: one line of reasoning stating how the claims beneath it combine to bear on the claim above it, for or against. Arguments are not destinations; click their claims to explore.constitution →✓verifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →↑supportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →⇄contestedCredible evidence or argument exists on multiple sides.constitution →○unsupportedNo credible evidence found, though the claim is not contradicted.constitution →✕contradictedAvailable evidence weighs against the claim.constitution →?unknownInsufficient information to assess.constitution →◌unassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →verified factopen questionvalue premisesupportsthis provides evidence for the parentsteward instructions →contradictsthis argues against the parentsteward instructions →assumesbackground the parent's framing takes as givensteward instructions →requiresa load-bearing premise: the parent is false without itsteward instructions →Fig. Detail falls off with distance; every claim is an address.